(R)-(-)-Epichlorohydrin

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (R)-(-)-Epichlorohydrin are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (R)-(-)-Epichlorohydrin?

The molecule (R)-(-)-Epichlorohydrin presents a molecular formula of C3H5ClO and its IUPAC name is (2R)-2-(chloromethyl)oxirane.

Epichlorohydrin, also known as 1-chloro-2,3-epoxypropane, is an organic compound with the formula CH2=CHC(O)Cl. It is a colorless, viscous liquid with a chloroform-like odor. It is produced on a large scale as a precursor to many epoxy resins..

Epichlorohydrin is produced by the chlorination of propylene:.

CH3CH=CH2 + Cl2 → CH2=CHC(O)Cl + HCl.

The reaction is conducted at 50-60 °C and 1-2 atm in the presence of a catalyst, typically Al2O3, Fe2O3, or SiO2. .

Epichlorohydrin is a chiral molecule. The (R)-(-)-enantiomer is produced commercially, whereas the (S)-(+)-enantiomer is produced naturally by some species of algae..

The major use of epichlorohydrin is in the production of epoxy resins, which are used as adhesives, coatings, and composites. Epoxy resins are produced by the reaction of epichlorohydrin with bisphenol A:.

CH2=CHC(O)Cl + 2 H2C(O)Ph → (H2C(O)Ph)2C(O)Cl + 2 HCl.

Epichlorohydrin is also used as a biocide and as a precursor to other organic chemicals, such as glycerol chlorohydrins and epibatidine..

Health and safety.

Epichlorohydrin is a highly reactive molecule and lies as a hazardous substance. It is a skin and eye irritant and can cause liver and kidney damage. Inhalation of epichlorohydrin vapor can cause irritation of the respiratory tract..

3D structure

Cartesian coordinates

Geometry of (R)-(-)-Epichlorohydrin in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

(R)-(-)-Epichlorohydrin BRLQWZUYTZBJKN-VKHMYHEASA-N chemical compound 2D structure molecule svg
(R)-(-)-Epichlorohydrin

 

Molecule descriptors

 
IUPAC name(2R)-2-(chloromethyl)oxirane
InChI codeInChI=1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m0/s1
InChI KeyBRLQWZUYTZBJKN-VKHMYHEASA-N
SMILESClC[C@H]1CO1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (-)-Epichlorohydrin
  • (2R)-(-)-3-Chloro-1,2-propenoxide
  • (2R)-2-(chloromethyl)oxirane
  • (R)(-)epichlorohydrin
  • (R)-(-)-2-(Chloromethyl)oxirane
  • (R)-(-)-Epichlorohydrin
  • (R)-(-)-epichlorhydrine
  • (R)-(-)Epichlorhydrin
  • (R)-(-)epichlorhydrine
  • (R)-(Chloromethyl)oxirane
  • (R)-1-Chloro-2,3-epoxypropane
  • (R)-2-(Chloromethyl)Oxirane
  • (R)-2-(chloromethyl) oxirane
  • (R)-2-chloromethyl-oxirane
  • (R)-3-Chloropropylene Oxide
  • (R)-3-chloro-1,2-epoxypropane
  • (R)-Chloromethyl oxirane
  • (R)-Chloromethyloxirane
  • (R)-Epichlorohydrin
  • (R)-epi-chlorohydrin
  • (R,S)-2-Chloromethyl-oxirane
  • (r)-(+)-epichlorohydrin
  • (r)-(-)-1-chloro-2,3-epoxypropane
  • (r)-(-)-chloromethyloxirane
  • (r)-(-)-epiclorohydrin
  • (r)-(-)-epichlorohydrine
  • (r)-(-)epichlorohydrin
  • (r)-epichlorohydrine
  • 2-(Chloromethyl)oxirane #
  • 51594-55-9
  • 594E559
  • A828677
  • AC-7036
  • ACT02845
  • AM20090812
  • BCP08874
  • BRN 1420785
  • CCRIS 6387
  • CS-0005957
  • E0581
  • EC 424-280-2
  • Epichlorohydrin, (-)-
  • J-524218
  • LS30047
  • MFCD00077759
  • Oxirane, (chloromethyl)-, (2R)-
  • Oxirane, (chloromethyl)-, (R)-
  • Oxirane, 2-(chloromethyl)-, (2R)-
  • Q26840862
  • R-(-) epichlorohydrin
  • R-(-)-Epichlorohydrin
  • R-(-)-epichlorhydrin
  • R-epi-chlorohydrin
  • STR07309
  • VEC01H609I
  • r-epichlorohydrin
  • r-epichlorohydrine

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC2016052
  • UNII-VEC01H609I
  • AKOS006240274
  • AKOS015848754
  • DTXSID501014417
  • CHEMBL448626
  • CHEBI:18662

Physico-Chemical properties

IUPAC name(2R)-2-(chloromethyl)oxirane
Molecular formulaC3H5ClO
Molecular weight92.5242
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity20.30
LogP0.6
Topological polar surface area12.5

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.