(R)-colchicine

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (R)-colchicine are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (R)-colchicine?

The molecule (R)-colchicine presents a molecular formula of C22H25NO6 and its IUPAC name is N-[(7R)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide.

Colchicine is a medication most commonly used to treat gout. It is a natural product derived from the Colchicum autumnale plant, also known as the autumn crocus. Colchicine works by reducing inflammation and pain. It exists as a generic medication and is not very expensive..

3D structure

Cartesian coordinates

Geometry of (R)-colchicine in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

(R)-colchicine IAKHMKGGTNLKSZ-MRXNPFEDSA-N chemical compound 2D structure molecule svg
(R)-colchicine

 

Molecule descriptors

 
IUPAC nameN-[(7R)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
InChI codeInChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m1/s1
InChI KeyIAKHMKGGTNLKSZ-MRXNPFEDSA-N
SMILESCOc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@H](NC(C)=O)CC2

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (+)-Colchicine
  • (R)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
  • (R)-colchicine
  • 75520-89-7
  • Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (R)-
  • CCG-35801
  • CCG-36032
  • COLCHICINE natural
  • COLCHICINE, (+)-
  • Lopac-C-9754
  • N-[(7R)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
  • N-[(7R)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • NCGC00015286-01
  • NCGC00016293-01
  • NCGC00017162-01
  • NCGC00017162-02
  • NCGC00142480-01
  • NCIMech_000874
  • Oprea1_777295
  • Q27122333
  • TNP00005

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC607790
  • CAS-64-86-8
  • DTXSID60226466
  • CHEMBL330320
  • CHEBI:51074
  • SCHEMBL15521905

Physico-Chemical properties

IUPAC nameN-[(7R)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Molecular formulaC22H25NO6
Molecular weight399.437
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity109.36
LogP3.3
Topological polar surface area83.1

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.