(s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide?

The molecule (s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide presents a molecular formula of C6H10N2O3 and its IUPAC name is 2-[(4S)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide.

S-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide is a molecule with the chemical formula C6H9NO3. It is a white solid that is soluble in water..

This molecule is an inhibitor of the enzyme acetylcholinesterase. Acetylcholinesterase is responsible for the breakdown of the neurotransmitter acetylcholine. Inhibition of this enzyme leads to an increase in acetylcholine levels..

S-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide has been shown to improve cognitive function in animal studies. It is thought to work by increasing levels of acetylcholine in the brain..

Clinical trials are currently underway to test the safety and efficacy of this compound in humans..

3D structure

Cartesian coordinates

Geometry of (s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

(s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide IHLAQQPQKRMGSS-BYPYZUCNSA-N chemical compound 2D structure molecule svg
(s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide

 

Molecule descriptors

 
IUPAC name2-[(4S)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide
InChI codeInChI=1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)/t4-/m0/s1
InChI KeyIHLAQQPQKRMGSS-BYPYZUCNSA-N
SMILESNC(=O)CN1C[C@@H](O)CC1=O

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (4S)-4-Hydroxy-2-oxo-1-pyrrolidineacetamide
  • (S)-4-Hydroxy-2-oxo-1-pyrrolidineacetamide
  • (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide
  • (S)-ISF-2522
  • (S)-OXIRACETAM
  • (s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide
  • (s)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide
  • 1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (S)-
  • 2-[(4S)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide
  • 88929-35-5
  • A14281
  • BS-49207
  • E84819
  • Lopac-O-3011
  • MFCD00920793
  • NCGC00015768-01
  • S-OXIRACETAM

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC3792328
  • AKOS022172828
  • DTXSID201317414
  • CHEMBL1472936
  • SCHEMBL2596758

Physico-Chemical properties

IUPAC name2-[(4S)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide
Molecular formulaC6H10N2O3
Molecular weight158.155
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity39.92
LogP-1.3
Topological polar surface area83.6

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.