(R)-(+)-Pantoprazole

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (R)-(+)-Pantoprazole are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (R)-(+)-Pantoprazole?

The molecule (R)-(+)-Pantoprazole presents a molecular formula of C16H15F2N3O4S and its IUPAC name is 6-(difluoromethoxy)-2-[(R)-(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole.

Pantoprazole, sold under the brand name Protonix among others, is a medication used for the treatment of gastric acid-related disorders.[1] Specifically, it is used for the treatment of erosive esophagitis, peptic ulcer disease, gastroesophageal reflux disease (GERD), and Zollinger–Ellison syndrome.[1] It is taken by mouth or intravenously.[1].

Common side effects include headache, diarrhea, and abdominal pain.[1] Serious side effects may include low blood magnesium, C. difficile colitis, and pneumonia.[1] Use in pregnancy may be harmful.[1] Pantoprazole is a proton pump inhibitor (PPI).[1].

Pantoprazole was patented in 1981 and approved for medical use in 1990.[2][3] It exists as a generic medication.[1] In 2018, it was the 134th most commonly prescribed medication in the United States, with more than 11 million prescriptions.[4].

Pantoprazole is used for short-term treatment of erosion and ulceration of the esophagus for adults and children 5 years of age and older.[5][6].

Pantoprazole is used for the treatment of active duodenal ulcer in adults.[7].

Pantoprazole is used for maintaining healing and symptom relief of erosive or ulcerative gastroesophageal reflux disease (GERD).[8][9].

Pantoprazole is used in the treatment of Zollinger-Ellison syndrome.[10][11].

Pantoprazole, given intravenously (into a vein) or orally (by mouth), is used for the short-term treatment (4 to 8 weeks) in the healing and symptom relief of erosive esophagitis.[12][13].

Pantoprazole, given intravenously, is used for the treatment of heartburn and stomach acid reflux in adults and children 3 months of age and older.[14].

3D structure

Cartesian coordinates

Geometry of (R)-(+)-Pantoprazole in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

(R)-(+)-Pantoprazole IQPSEEYGBUAQFF-AREMUKBSSA-N chemical compound 2D structure molecule svg
(R)-(+)-Pantoprazole

 

Molecule descriptors

 
IUPAC name6-(difluoromethoxy)-2-[(R)-(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
InChI codeInChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)/t26-/m1/s1
InChI KeyIQPSEEYGBUAQFF-AREMUKBSSA-N
SMILESCOc1ccnc(C[S@@](=O)c2nc3ccc(OC(F)F)cc3[nH]2)c1OC

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (+)-(R)-Pantoprazole
  • (+)-Pantoprazole
  • (R)-(+)-Pantoprazole
  • (R)-Pantoprazole
  • 142706-18-1
  • 1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-, (+)-
  • 1H-Benzimidazole, 5-(difluoromethoxy)-2-((R)-((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-
  • 1H-Benzimidazole, 6-(difluoromethoxy)-2-((R)-((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-
  • 6-(Difluoromethoxy)-2-((R)-((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole
  • 6-(difluoromethoxy)-2-[(R)-(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
  • 8UUN42B3QT
  • BDBM50409893
  • Pantoprazole, (R)-
  • R-Pantoprazole

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC4676424
  • UNII-8UUN42B3QT
  • CHEMBL2096747
  • SCHEMBL22198

Physico-Chemical properties

IUPAC name6-(difluoromethoxy)-2-[(R)-(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
Molecular formulaC16H15F2N3O4S
Molecular weight383.37
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity90.36
LogP3.8
Topological polar surface area105.5

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.