Hydrocortisone

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Hydrocortisone are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the Hydrocortisone?

The molecule Hydrocortisone presents a molecular formula of C21H30O5 and its IUPAC name is (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one.

Hydrocortisone is a steroid hormone that is produced by the adrenal gland. It participes in a variety of physiological processes, including stress response, immune function, and inflammation. Hydrocortisone is also a medication that is used to treat a variety of conditions, including allergies, asthma, and arthritis..

Hydrocortisone is a steroid hormone that is produced by the adrenal gland. It participes in a variety of physiological processes, including stress response, immune function, and inflammation. Hydrocortisone is also a medication that is used to treat a variety of conditions, including allergies, asthma, and arthritis..

Hydrocortisone is a steroid hormone that is produced by the adrenal gland. It participes in a variety of physiological processes, including stress response, immune function, and inflammation. Hydrocortisone is also a medication that is used to treat a variety of conditions, including allergies, asthma, and arthritis..

Hydrocortisone is a steroid hormone that is produced by the adrenal gland. It participes in a variety of physiological processes, including stress response, immune function, and inflammation. Hydrocortisone is also a medication that is used to treat a variety of conditions, including allergies, asthma, and arthritis..

3D structure

Cartesian coordinates

Geometry of Hydrocortisone in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

Hydrocortisone JYGXADMDTFJGBT-VWUMJDOOSA-N chemical compound 2D structure molecule svg
Hydrocortisone

 

Molecule descriptors

 
IUPAC name(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
InChI codeInChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI KeyJYGXADMDTFJGBT-VWUMJDOOSA-N
SMILESC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (10R,13S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • (11alpha,14beta)-11,17,21-Trihydroxypregn-4-Ene-3,20-Dione
  • (11beta)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione
  • (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
  • (1S,10S,11S,15S,17S,2R,14R)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyl tetracyclo[8.7.0.0<2,7>.0<11,15>]heptadec-6-en-5-one
  • (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
  • (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
  • (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
  • 11,17,21-Trihydroxypregn-4-ene-3,20-dione
  • 11,17,21-Trihydroxypregn-4-ene-3,20-dione, (11.beta.)-
  • 11-Hydrocortisone
  • 11-beta-Hydrocortisone
  • 11-beta-Hydroxycortisone
  • 11.beta.,17,21-Trihydroxypregn-4-ene-3,20-dione
  • 11.beta.,17,21-trihydroxyprogesterone
  • 11.beta.,17.alpha.,21-Trihydroxy-4-pregnene-3,20-dione
  • 11.beta.,17.alpha.,21-Trihydroxypregn-4-ene-3,20-dione
  • 11.beta.-Hydrocortisone
  • 11.beta.-Hydroxycortisone
  • 11?,17?,21-Trihydroxypregn-4-ene-3,20-dione
  • 11a-Hydroxycorticosterone
  • 11alpha-Hydroxycorticosterone
  • 11b,17,21-Trihydroxyprogesterone
  • 11b-Hydrocortisone
  • 11b-Hydroxycortisone
  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione
  • 11beta,17,21-Trihydroxyprogesterone
  • 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
  • 11beta,17alpha,21-Trihydroxypregn-4-ene-3,20-dione
  • 11beta-Hydrocortisone
  • 11beta-Hydroxycortisone
  • 11beta-cortisol
  • 17-Hydroxycorticosterone
  • 17.alpha.-Hydroxycorticosterone
  • 17a-Hydroxycorticosterone
  • 17alpha-Hydroxycorticosterone
  • 2v95
  • 3h-cortisol
  • 4-(6-chloro-4-oxoquinazolin-3(4H)-yl)-N-(3-methoxyphenyl)piperidine-1-carboxamide
  • 4-Pregnen-11.beta.,17.alpha.,21-triol-3,20-dione
  • 4-Pregnen-11beta,17alpha,21-triol-3,20-dione
  • 4-Pregnene-11.beta.,17.alpha.,21-triol-3,20-dione
  • 4-Pregnene-11alpha,21-triol 3,20-dione
  • 4-Pregnene-11b,17a,21-triol-3,20-dione
  • 4-Pregnene-11beta,17alpha,21-triol-3,20-dione
  • 4p6x
  • 50-23-7
  • 50H237
  • A929789
  • AC-12902
  • ACETASOL HC COMPONENT HYDROCORTISONE
  • AI3-25006
  • ALKINDI SPRINKLE
  • ALPHADERM COMPONENT HYDROCORTISONE
  • AS-11651
  • Acticort
  • Aeroseb HC
  • Aeroseb-HC
  • Ala-Cort
  • Ala-Scalp
  • Alacort
  • Algicirtis
  • Alphaderm
  • Amberin
  • Anflam
  • Anti-inflammatory hormone
  • Anucort
  • Anucort-HC
  • Anusol HC
  • Aquacort
  • Aquanil HC
  • B1951
  • B48448A1-24BA-47CA-8D9E-43E5BC949386
  • BCP09054
  • BDBM13775
  • BP-20390
  • BPBio1_000544
  • BSPBio_000494
  • Balneol-hc
  • Barseb HC
  • Basan-Corti
  • Beta-hc
  • C00735
  • CALMURID HC COMPONENT HYDROCORTISONE
  • CCG-204683
  • CCRIS 5854
  • CIPRO HC COMPONENT HYDROCORTISONE
  • COR-OTICIN
  • CaldeCORT Spray
  • Cetacort
  • Clear aid
  • Cleiton
  • Cobadex
  • Colocort
  • Compound F
  • Compound F (kendall)
  • Corhydron
  • Cort-Dome
  • Cortanal
  • Cortef
  • Cortenema
  • Cortesal
  • Corticreme
  • Cortifan
  • Cortiment
  • Cortisol
  • Cortisol alcohol
  • Cortisolonum
  • Cortisporin
  • Cortisporin Otico
  • Cortispray
  • Cortizol
  • Cortolotion
  • Cortonema
  • Cortoxide
  • Cortril
  • Cremesone
  • Cremicort-H
  • Cutisol
  • Chronocort
  • D00088
  • DB00741
  • DSSTox_CID_714
  • DSSTox_GSID_20714
  • DSSTox_RID_75753
  • Delacort
  • Derm-Aid
  • Dermacort
  • Dermaspray
  • Dermil
  • Dermocortal
  • Dermolate
  • Dihydrocostisone
  • Dioderm
  • Dome-cort
  • Domolene-HC
  • Drotic
  • DuoCort
  • EC 200-020-1
  • EU-0100594
  • Ef corlin
  • Efcorbin
  • Efcortelan
  • Efcortelin
  • Efmody
  • Eldecort
  • Eldercort
  • Epicort
  • Epiderm H
  • Epitope ID:174851
  • Esiderm H
  • Evacort
  • Ficortril
  • Fiocortril
  • Flexicort
  • Foille Insetti
  • GTPL2868
  • Genacort
  • Genacort (lotion)
  • Glycort
  • Gyno-Cortisone
  • H 4001
  • H-Cort
  • HC
  • HC #1
  • HC #4
  • HC (HYDROCORTISONE)
  • HMS1569I16
  • HMS2090M04
  • HMS2096I16
  • HMS2230B18
  • HMS2235F17
  • HMS3259C05
  • HMS3261H10
  • HMS3713I16
  • HSDB 3339
  • HY-N0583
  • HYDROCORTISONE COMPONENT OF ACETASOL HC
  • HYDROCORTISONE COMPONENT OF ALPHADERM
  • HYDROCORTISONE COMPONENT OF CALMURID HC
  • HYDROCORTISONE COMPONENT OF CIPRO HC
  • HYDROCORTISONE COMPONENT OF ORLEX HC
  • HYDROCORTISONE COMPONENT OF OTICAIR
  • HYDROCORTISONE COMPONENT OF OTOBIONE
  • HYDROCORTISONE COMPONENT OF OTOBIOTIC
  • HYDROCORTISONE COMPONENT OF OTOCORT
  • HYDROCORTISONE COMPONENT OF PEDIOTIC
  • HYDROCORTISONE COMPONENT OF PYOCIDIN
  • HYDROCORTISONE COMPONENT OF VOSOL HC
  • HYDROCORTISONE IN ABSORBASE
  • Heb Cort
  • Heb-Cort
  • Hidalone
  • Hidro-Colisona
  • Hidrocortisona
  • Hycort
  • Hycortol
  • Hycortole
  • Hydracort
  • Hydrasson
  • Hydro-Adreson
  • Hydro-Colisona
  • Hydro-RX
  • Hydrocort
  • Hydrocortal
  • Hydrocorticosterone
  • Hydrocortisone
  • Hydrocortisone (Cortisol)
  • Hydrocortisone (JP17/USP/INN)
  • Hydrocortisone alcohol
  • Hydrocortisone base
  • Hydrocortisone free alcohol
  • Hydrocortisone, meets USP testing specifications
  • Hydrocortisone, topical
  • Hydrocortisonum
  • Hydrocortisyl
  • Hydrocortone
  • Hydroskin
  • Hydroxycortisone
  • Hysone
  • Hytisone
  • Hytone
  • Hytone lotion
  • Idrocortisone
  • Incortin-H
  • Incortin-hydrogen
  • Kendall's compound F
  • Komed HC
  • Kyypakkaus
  • LMST02030001
  • LP00594
  • Lacticare HC
  • Lacticare-HC
  • Lactisona
  • Lopac0_000594
  • Lubricort
  • MFCD00011654
  • MLS000069609
  • MLS001148103
  • MLS002207135
  • MLS002222189
  • MLS002548868
  • Maintasone
  • Medicort
  • Meusicort
  • Mildison
  • Milliderm
  • NC00456
  • NCGC00022848-06
  • NCGC00022848-07
  • NCGC00022848-09
  • NCGC00022848-10
  • NCGC00022848-11
  • NCGC00022848-12
  • NCGC00022848-13
  • NCGC00022848-14
  • NCGC00022848-15
  • NCGC00022848-17
  • NCGC00022848-26
  • NCGC00258369-01
  • NCGC00261279-01
  • NCI60_000118
  • NSC 10483
  • NSC-10483
  • NSC10483
  • Neo-Cort-Dome
  • Neosporin-H Ear
  • Nogenic HC
  • Nutracort
  • Nystaform-HC
  • ORLEX HC COMPONENT HYDROCORTISONE
  • OTICAIR COMPONENT HYDROCORTISONE
  • OTOBIONE COMPONENT HYDROCORTISONE
  • OTOBIOTIC COMPONENT HYDROCORTISONE
  • OTOCORT COMPONENT HYDROCORTISONE
  • Opera_ID_1292
  • Ophthocort
  • Optef
  • Otalgine
  • Otic-Neo-Cort-Dome
  • Otobiotic
  • Otocort
  • Otosone-F
  • PEDIOTIC COMPONENT HYDROCORTISONE
  • PYOCIDIN COMPONENT HYDROCORTISONE
  • Pediotic Suspension
  • Penecort
  • Permicort
  • Plenadren
  • Polcort H
  • Pregn-4-ene-3, 11,17,21-trihydroxy-, (11.beta.)-
  • Pregn-4-ene-3, 11.beta.,17,21-trihydroxy-
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11-beta)-
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11b)-
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
  • Pregn-4-ene-3,20-dione, 11.beta.,17,21-trihydroxy-
  • Pregn-4-ene-3,20-dione, 11beta,17,21-trihydroxy-
  • Preparation H Hydrocortisone Cream
  • Prepcort
  • Prestwick0_000447
  • Prestwick1_000447
  • Prestwick2_000447
  • Prestwick3_000447
  • Prestwick_265
  • Prevex HC
  • Proctocort
  • Proctofoam
  • Proctosol-HC
  • Proctozone HC
  • Protocort
  • Q-201211
  • Q190875
  • Racet
  • Rectasol-HC
  • Rectoid
  • Reichstein's substance M
  • Remederm HC
  • SDCCGSBI-0050576.P003
  • SMP1_000156
  • SMR000059022
  • SMR000653523
  • SR-01000000139
  • SR-01000000139-3
  • Sanatison
  • Scalp-Cort
  • Scalpicin Capilar
  • Schericur
  • Scheroson F
  • Sigmacort
  • Signef
  • Stie-cort
  • Stiefcorcil
  • Synacort
  • Systral Hydrocort
  • Tarcortin
  • Terra-cortril
  • Texacort
  • Texacort lotion 25
  • Timocort
  • Transderma H
  • Traumaide
  • U 1851
  • Uniderm
  • VOSOL HC COMPONENT HYDROCORTISONE
  • VoSol HC
  • Vytone
  • WI4X0X7BPJ
  • Z2786051549
  • Zenoxone
  • [3H]cortisol
  • component of Lubricort
  • component of Neo-Cort-Dome
  • component of Otalgine
  • hydrocortisone
  • s1696

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC13540519
  • CAS-50-23-7
  • UNII-WI4X0X7BPJ
  • AKOS001582651
  • BRD-K93568044-001-03-1
  • BRD-K93568044-001-11-4
  • BRD-K93568044-001-32-0
  • DTXSID7020714
  • CHEMBL389621
  • CHEBI:17650
  • Tox21_110883
  • Tox21_200815
  • Tox21_500594
  • Tox21_110883_1
  • EINECS 200-020-1
  • SPBio_002433
  • UPCMLD-DP133
  • UPCMLD-DP133:001
  • SCHEMBL4148

Physico-Chemical properties

IUPAC name(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Molecular formulaC21H30O5
Molecular weight362.46
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity97.53
LogP1.8
Topological polar surface area94.8

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.