A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Epoprostenol are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the Epoprostenol?

The molecule Epoprostenol presents a molecular formula of C20H32O5 and its IUPAC name is (5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid.

Epoprostenol is a molecule that is used in the treatment of pulmonary arterial hypertension (PAH). It is a prostaglandin analogue that works by relaxing the smooth muscle cells in the walls of the blood vessels, which leads to an increase in blood flow and a decrease in blood pressure. Epoprostenol exists as a brand-name drug called Flolan and can be found as a generic drug..

3D structure

Cartesian coordinates

Geometry of Epoprostenol in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing


Epoprostenol KAQKFAOMNZTLHT-OZUDYXHBSA-N chemical compound 2D structure molecule svg


Molecule descriptors

IUPAC name(5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
InChI codeInChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (5Z)-5-[(3Ar,4R,5R,6aR)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
  • (5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
  • (5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[d]furan-2-ylidene]pentanoic acid
  • (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoic acid
  • (5Z,9alpha,11alpha,13E,15S)-11,15-dihydroxy-6,9-epoxyprosta-5,13-dien-1-oic acid
  • (5Z,9alpha,11alpha,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid
  • (Z)-(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S)-3-hydroxy-1-octenyl)-2H-cyclopenta(b)furan-delta(sup 2,delta)-valeric acid
  • (Z)-5-((3aR,4R,5R,6aS)-5-hydroxy-4-((S,E)-3-hydroxyoct-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-ylidene)pentanoic acid
  • 35121-78-9
  • 6,9-alpha-Epoxy-11-alpha,15(S)-dihydroxyprosta-5(Z),13(E)-dien-1-oic acid
  • 6,9.alpha.-Epoxy-11.alpha.,15S-dihydroxyprosta-5Z,13E-dien-1-oic acid, monosodium salt
  • 6,9S-epoxy-11R,15S-dihydoxy-5Z,13E-prostadienoic acid
  • 63859-31-4
  • ACT-385781A
  • BIDD:GT0514
  • BRN 1690090
  • BSPBio_001496
  • CS-0017443
  • DB01240
  • DCR9Z582X0
  • Epoprostenol
  • Epoprostenolum
  • Flolan
  • GTPL1915
  • HMS1791K18
  • HMS1989K18
  • HMS3402K18
  • HY-A0126
  • IDI1_033966
  • KB-IV-24
  • LMFA03010087
  • NCGC00161285-01
  • NCGC00161285-02
  • NCGC00161285-03
  • PG-I2
  • PGI(sub 2)
  • PGI2
  • PGX
  • PROSTA-5,13-DIEN-1-OIC ACID, 6,9-EPOXY-11,15-DIHYDROXY-, (5Z,9.ALPHA.,11.ALPHA.,13E,15S)-
  • Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-
  • Prosta-5,13-dien-1-oicacid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9a,11a,13E,15S)-
  • Prostacyclin I2
  • Prostaglandin 12
  • Prostaglandin X
  • Q412050
  • SMP2_000227
  • U 53,217
  • U 53217
  • U-53,217
  • U-53217
  • Vasocyclin
  • VentaProst
  • epoprostenol
  • prostacyclin
  • prostaglandin I2

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC3813078
  • UNII-DCR9Z582X0
  • BRD-K64054020-001-02-7
  • DTXSID5022988
  • CHEMBL1139
  • CHEBI:15552
  • SCHEMBL8041

Physico-Chemical properties

IUPAC name(5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid
Molecular formulaC20H32O5
Molecular weight352.465
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity98.26
Topological polar surface area87.0

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.