GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc?

The molecule GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc presents a molecular formula of C28H44N2O23 and its IUPAC name is (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4S,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid.

GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc is a molecule that participes in the biosynthesis of the glycosaminoglycan hyaluronic acid. This molecule is a substrate for the enzyme hyaluronan synthase, which catalyzes the transfer of the sugar GlcA from UDP-GlcA to the acceptor molecule GlcNAc. The product of this reaction is GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc, which is then further modified by other enzymes to yield hyaluronic acid..

Hyaluronic acid is a polysaccharide that belongs in the extracellular matrix of tissues, where it serves as a lubricant and shock absorber. This molecule is also involved in cell-to-cell communication, and it plays a role in wound healing. In addition, hyaluronic acid is a major component of the synovial fluid that lubricates joints..

GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc is a necessary intermediate in the biosynthesis of hyaluronic acid, and thus it is essential for the proper function of this molecule..

3D structure

Cartesian coordinates

Geometry of GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc KIUKXJAPPMFGSW-DRDGCVDESA-N chemical compound 2D structure molecule svg
GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc

 

Molecule descriptors

 
IUPAC name(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4S,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
InChI codeInChI=1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18+,19-,20+,21+,22+,25-,26+,27-,28-/m1/s1
InChI KeyKIUKXJAPPMFGSW-DRDGCVDESA-N
SMILESCC(=O)N[C@@H]1[C@H](O[C@@H]2O[C@H](C(=O)O)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@@H]4O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](CO)O[C@H]1O

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)b-AllNAc

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC96014307

Physico-Chemical properties

IUPAC name(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4S,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Molecular formulaC28H44N2O23
Molecular weight776.649
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity157.01
LogP-8.5
Topological polar surface area399.7

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.