[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl phosphate

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for [(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl phosphate are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is [(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl phosphate?

The molecule [(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl phosphate presents a molecular formula of C5H9O8P-2 and its IUPAC name is [(2R,3S,4R,5R)-3,4,5-tris(oxidanyl)oxolan-2-yl]methyl phosphate.

3D structure

Cartesian coordinates

Geometry of [(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl phosphate in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl phosphate KTVPXOYAKDPRHY-TXICZTDVSA-L chemical compound 2D structure molecule svg
[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl phosphate

 

Molecule descriptors

 
IUPAC name[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl phosphate
InChI codeInChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/p-2/t2-,3-,4-,5-/m1/s1
InChI KeyKTVPXOYAKDPRHY-TXICZTDVSA-L
SMILESC([C@@H]1[C@H]([C@H]([C@@H](O1)O)O)O)OP(=O)([O-])[O-]

Physico-Chemical properties

IUPAC name[(2R,3S,4R,5R)-3,4,5-tris(oxidanyl)oxolan-2-yl]methyl phosphate
Molecular formulaC5H9O8P-2
Molecular weight228.09
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity
LogP-3.8
Topological polar surface area142

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.