Benzamide

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Benzamide are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the Benzamide?

The molecule Benzamide presents a molecular formula of C7H7NO and its IUPAC name is benzamide.

Benzamide is a molecule with the chemical formula C6H5CONH2. It is a white solid that is soluble in water and polar organic solvents. It has a faint amine-like odor. Benzamide is used as a starting material for the synthesis of many other organic compounds. It is also used as an insecticide and as a corrosion inhibitor..

The structure of benzamide is similar to that of benzoic acid, except that the amide group replaces the carboxylic acid group. The amide group is a group of atoms that includes a nitrogen atom bonded to two hydrogen atoms. The amide group belongs in many other molecules, including proteins and drugs..

Benzamide is produced by the reaction of benzoic acid with ammonia. This reaction is called amination..

Benzamide can also be produced by the reaction of benzoyl chloride with ammonia. This reaction is called chlorination..

Benzamide is used as a starting material for the synthesis of many other organic compounds. For example, it can be converted into p-aminobenzoic acid, which is used as an ingredient in sunscreen. It can also be converted into aniline, which is used in the manufacture of dyes and plastics..

Benzamide is also used as an insecticide. It is effective against a variety of insects, including cockroaches, ants, and termites..

Benzamide is also used as a corrosion inhibitor. It is added to metal surfaces to prevent the formation of rust..

3D structure

Cartesian coordinates

Geometry of Benzamide in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

Benzamide KXDAEFPNCMNJSK-UHFFFAOYSA-N chemical compound 2D structure molecule svg
Benzamide

 

Molecule descriptors

 
IUPAC namebenzamide
InChI codeInChI=1S/C9H10O2/c1-8(10)11-7-9-5-3-2-4-6-9/h2-6H,7H2,1H3
InChI KeyKXDAEFPNCMNJSK-UHFFFAOYSA-N
SMILESC(=O)(c1ccccc1)N

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:

Physico-Chemical properties

IUPAC namebenzamide
Molecular formulaC7H7NO
Molecular weight121.137
Melting point (ºC)129
Boiling point (ºC)-
Density (g/cm3)-
Molar refractivity34.54
LogP1.5
Topological polar surface area26.3

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.