A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Periciazine are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the Periciazine?

The molecule Periciazine presents a molecular formula of C18H21NO5 and its IUPAC name is 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile.

Periciazine is a molecule that has shown potential as a treatment for Alzheimer's disease. It is a derivative of the antipsychotic drug chlorpromazine, and works by blocking the action of the neurotransmitter acetylcholine..

Periciazine has been shown to improve memory and cognitive function in animal studies, and has also been shown to be effective in treating the symptoms of Alzheimer's disease in humans..

There is currently no cure for Alzheimer's disease, and available treatments only offer symptomatic relief. Periciazine has the potential to be a disease-modifying treatment, and could potentially slow or halt the progression of Alzheimer's disease..

Further research is needed to confirm the efficacy of periciazine in treating Alzheimer's disease, and to assess its safety and tolerability..

3D structure

Cartesian coordinates

Geometry of Periciazine in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing


Periciazine LUMAEVHDZXIGEP-ZBEGNZNMSA-N chemical compound 2D structure molecule svg


Molecule descriptors

IUPAC name10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
InChI codeInChI=1S/C18H21NO5/c1-11(6-12-2-5-17-18(7-12)24-10-23-17)19-9-16(22)13-3-4-14(20)15(21)8-13/h2-5,7-8,11,16,19-22H,6,9-10H2,1H3/t11-,16-/m0/s1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • 10-(3-(4-Hydroxypiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile
  • 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile
  • 10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile #
  • 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
  • 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
  • 10H-Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxy-1-piperidinyl)propyl]-
  • 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine
  • 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine
  • 2622-26-6
  • 3405M6FD73
  • 4-Piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)-
  • 6909 RP
  • Aolept
  • BDBM50346422
  • BRN 0576739
  • BSPBio_002336
  • Bayer 1409
  • CCG-39062
  • CS-0002963
  • Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine
  • D01485
  • DB01608
  • DSSTox_CID_25910
  • DSSTox_GSID_45910
  • DSSTox_RID_81221
  • DivK1c_000874
  • F.I. 6145
  • FT-0673633
  • GTPL9216
  • HMS1922M18
  • HMS502L16
  • HY-14263
  • IC 6002
  • IDI1_000874
  • KBio1_000874
  • KBio2_002094
  • KBio2_004662
  • KBio2_007230
  • KBio3_001556
  • KBioGR_000819
  • KBioSS_002094
  • NCGC00095086-01
  • NCGC00095086-02
  • NCGC00095086-03
  • NCGC00095086-04
  • NINDS_000874
  • NSC 758641
  • NSC-758641
  • NSC758641
  • Nelactil
  • Nemactil
  • Neulactil
  • Neuleptil
  • Periciazin
  • Periciazina
  • Periciazine
  • Periciazinum
  • Pharmakon1600-01503936
  • Phenothiazine-2-carbonitrile, 10-(3-(4-hydroxypiperidino)propyl)-
  • Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxypiperidino)propyl]-
  • Piperocyanomazine
  • Propericiazine
  • Propericiazine (JAN)
  • Propericiazine;RP 8909
  • Q2622907
  • RP 8908
  • RP 8909
  • RP 8909SKF 20716
  • RP-8909
  • SBI-0051867.P002
  • SKF 20,716
  • SKF 20716
  • SKF-20716
  • SPECTRUM1503936
  • SR-01000872777
  • SR-01000872777-1
  • WH 7508
  • periciazine
  • propericyazine
  • starbld0016671

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC538159
  • CAS-2622-26-6
  • UNII-3405M6FD73
  • BRD-K89669299-001-02-7
  • DTXSID5045910
  • CHEMBL251940
  • CHEBI:31981
  • Tox21_111417
  • EINECS 220-071-3
  • SPBio_001607
  • SCHEMBL148422
  • Spectrum_001614
  • Spectrum2_001604
  • Spectrum3_000748
  • Spectrum4_000210
  • Spectrum5_001747

Physico-Chemical properties

IUPAC name10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
Molecular formulaC18H21NO5
Molecular weight331.363
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity89.20
Topological polar surface area91.2

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.