Travoprost

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Travoprost are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the Travoprost?

The molecule Travoprost presents a molecular formula of C₂₆H₃₅F₃O₆ and its IUPAC name is propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate.

Travoprost is a synthetic prostaglandin analog used as a topical ophthalmic solution to treat glaucoma and ocular hypertension. It is a prodrug of travoprost acid, which is a selective agonist of the prostaglandin F2-alpha receptor. Travoprost is marketed by Alcon under the brand name Travatan..

Travoprost was approved by the United States Food and Drug Administration (FDA) in December 2001. In Europe, it was first approved in Sweden in June 2002. Travoprost is also approved in Canada, Brazil, and several other countries..

The most common side effects of travoprost are itching and redness of the eyes. Other rare side effects include changes in eyelash appearance, darkening of the iris, and growth of facial hair..

Travoprost is a prodrug of travoprost acid, which is a selective agonist of the prostaglandin F2-alpha receptor. The exact mechanism of action of travoprost is not known, but it is thought to lower intraocular pressure by increasing the outflow of aqueous humor..

Travoprost is a white powder that is soluble in organic solvents. It is formulated as a 0.004% solution for topical ophthalmic use..

Travoprost is typically used once daily in the evening. The recommended dosage is one drop in each eye..

Travoprost should be used with caution in patients with a history of hypersensitivity to prostaglandins. The most common side effects of travoprost are itching and redness of the eyes. Other rare side effects include changes in eyelash appearance, darkening of the iris, and growth of facial hair..

Travoprost is a safe and effective medication for the treatment of glaucoma and ocular hypertension. It is well tolerated with a low incidence of side effects..

3D structure

Cartesian coordinates

Geometry of Travoprost in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

Molecule descriptors

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

Reference codes for other databases

• CAS number (Chemical Abstracts Service Registry Number) is a unique identifier is assigned to every chemical compound indexed in the CAS database.
• Beilstein: The Beilstein database is a comprehensive source of information on organic chemistry, including information on chemical structures, properties, and reactions. The Beilstein database assigns unique identifiers which can be used to identify compounds in scientific literature and other sources.
• ChEBI (Chemical Entities of Biological Interest): ChEBI is a database of small chemical molecules that are of interest in the field of biology.
• PubChem CID (Compound Identifier): PubChem is a database of chemical compounds that is maintained by the National Institutes of Health (NIH).
• RTECS number (Registry of Toxic Effects of Chemical Substances): The RTECS is a database of information on the toxic effects of chemicals, including information on their structures and properties.
• ChEMBL (Compound Bioactivity Data): ChEMBL is a database of bioactivity data for small molecules, including information on their properties and structures.
• CompTox Dashboard (Environmental Protection Agency): The CompTox Dashboard is a database of information on the toxicology and environmental effects of chemicals.

Physico-Chemical properties

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (K_ow) data is applied in toxicology and drug research. K_ow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(K_ow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Ų are required. Thus, molecules with a polar surface area greater than 140 Ų tend to be poorly permeable to cell membranes.