Amineptine

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Amineptine are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the Amineptine?

The molecule Amineptine presents a molecular formula of C22H27NO2 and its IUPAC name is 7-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylamino)heptanoic acid.

Amineptine is a molecule that is structurally similar to the tricyclic antidepressants. It is a dopamine reuptake inhibitor, and also has some action as a norepinephrine reuptake inhibitor. Amineptine has been used as an antidepressant in some European and South American countries, but is not approved for use in the United States. There is some evidence that amineptine may be helpful in the treatment of dysthymia, and it has also been studied as a possible treatment for ADHD and cognitive impairment in the elderly..

3D structure

Cartesian coordinates

Geometry of Amineptine in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

Amineptine ONNOFKFOZAJDHT-UHFFFAOYSA-N chemical compound 2D structure molecule svg
Amineptine

 

Molecule descriptors

 
IUPAC name7-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylamino)heptanoic acid
InChI codeInChI=1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)
InChI KeyONNOFKFOZAJDHT-UHFFFAOYSA-N
SMILESO=C(O)CCCCCCNC1c2ccccc2CCc2ccccc21

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • 27T1I13L6G
  • 574A091
  • 57574-09-1
  • 7-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)heptanoic acid
  • 7-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylamino)heptanoic acid
  • A14998
  • Amineptin
  • Amineptine
  • Amineptine (INN)
  • Amineptino
  • Amineptinum
  • BDBM50292474
  • BRN 2170218
  • CS-1325
  • D07335
  • DB04836
  • DSSTox_CID_28757
  • DSSTox_GSID_48831
  • DSSTox_RID_83026
  • EU 1694
  • HEPTANOIC ACID, 7-((10,11-DIHYDRO-5H-DIBENZO(a,d)CYCLOHEPTEN-5-YL)AMINO)-
  • HY-16044
  • NCGC00183843-01
  • Q44822059
  • S 1694
  • Survector

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC2001740
  • CAS-57574-09-1
  • UNII-27T1I13L6G
  • AKOS030242481
  • DTXSID1048831
  • CHEMBL418995
  • CHEBI:32499
  • Tox21_113313
  • EINECS 260-818-0
  • SCHEMBL34086

Physico-Chemical properties

IUPAC name7-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylamino)heptanoic acid
Molecular formulaC22H27NO2
Molecular weight337.455
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity101.94
LogP4.9
Topological polar surface area49.3

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.