A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (S)-Warfarin are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (S)-Warfarin?

The molecule (S)-Warfarin presents a molecular formula of C19H16O4 and its IUPAC name is 4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]chromen-2-one.

S-Warfarin is an anticoagulant medication that is used to prevent blood clots from forming in the body. It is a synthetic version of the naturally occurring compound warfarin, which belongs in the herb sweet clover. S-Warfarin works by inhibiting the action of vitamin K, which is required for the blood-clotting process..

S-Warfarin was first synthesized in the early 1940s and was approved for use as an anticoagulant in the United States in 1954. It exists as a generic medication and is also sold under the brand names Coumadin and Jantoven..

The most common side effects of S-Warfarin include bleeding and bruising. More serious side effects include hemorrhage, stroke, and heart attack. S-Warfarin is contraindicated in people with active bleeding or a history of bleeding disorders..

S-Warfarin is a highly effective anticoagulant medication that has been used for over 60 years. It is important to use it correctly to minimize the risk of serious side effects..

3D structure

Cartesian coordinates

Geometry of (S)-Warfarin in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing


(S)-Warfarin PJVWKTKQMONHTI-HNNXBMFYSA-N chemical compound 2D structure molecule svg


Molecule descriptors

IUPAC name4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]chromen-2-one
InChI codeInChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m0/s1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (-)-Warfarin
  • (R)-(+)-Warfarin
  • (S)-(-)-Warfarin
  • (S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone
  • (S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
  • (S)-Warfarin
  • 1ha2
  • 2-hydroxy-3-[(1S)-3-oxo-1-phenyl-butyl]chromen-4-one
  • 2-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-4H-chromen-4-one
  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (S)-
  • 4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
  • 4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]chromen-2-one
  • 5543-57-7
  • A830639
  • A840201
  • BIDD:PXR0197
  • BIM-0061758.0001
  • C20129
  • Coumarin, 3-(.alpha.-acetonylbenzyl)-4-hydroxy-, (S)-(-)-
  • DB02507
  • DB14055
  • GS-6170
  • HP31W7FNP4
  • NCGC00165934-01
  • Q27093493
  • SWF
  • Warfarin, (S)-
  • levrowarfarin
  • s(-)-warfarin

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC3875543
  • ZINC100006264
  • AKOS027320629
  • AKOS037653253
  • BRD-K25991148-001-01-7
  • DTXSID50873382
  • CHEMBL251074
  • CHEBI:87738
  • EINECS 226-907-3
  • SCHEMBL20806
  • SCHEMBL662875

Physico-Chemical properties

IUPAC name4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]chromen-2-one
Molecular formulaC19H16O4
Molecular weight308.328
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity88.58
Topological polar surface area67.5

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.