(S)-Camazepam

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (S)-Camazepam are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (S)-Camazepam?

The molecule (S)-Camazepam presents a molecular formula of C19H18ClN3O3 and its IUPAC name is [(3S)-7-chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl] N,N-dimethylcarbamate.

(S)-Camazepam is a molecule of the benzodiazepine class. It is the active ingredient in the medication Librium, which is used to treat anxiety disorders and alcohol withdrawal..

The chemical structure of camazepam is very similar to that of other benzodiazepines, such as Valium and Xanax. Like other benzodiazepines, camazepam binds to a specific site on the GABA receptor, which is a protein that belongs in the brain..

GABA is a neurotransmitter that inhibits the activity of neurons. When camazepam binds to the GABA receptor, it increases the activity of GABA, which leads to a decrease in the activity of neurons. This action causes the sedative, anxiolytic, and muscle relaxant effects of camazepam..

Camazepam is metabolized in the liver and excreted in the urine. The half-life of camazepam is about 24 hours, which means that it takes about 24 hours for the body to eliminate half of the drug..

Librium exists in tablet form and is usually taken three or four times a day. The usual starting dose is 5 mg, but the dose may be increased or decreased depending on the response of the patient..

Patients who are taking camazepam should not drink alcohol or take other central nervous system depressants, such as opioids, because of the increased risk of side effects. Side effects of camazepam include drowsiness, dizziness, and lightheadedness..

Camazepam is a safe and effective medication when used as directed. However, like all medications, it has the potential for abuse and addiction. Patients who take camazepam should be monitored for signs of abuse and addiction..

3D structure

Cartesian coordinates

Geometry of (S)-Camazepam in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

(S)-Camazepam PXBVEXGRHZFEOF-KRWDZBQOSA-N chemical compound 2D structure molecule svg
(S)-Camazepam

 

Molecule descriptors

 
IUPAC name[(3S)-7-chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl] N,N-dimethylcarbamate
InChI codeInChI=1S/C19H18ClN3O3/c1-22(2)19(25)26-17-18(24)23(3)15-10-9-13(20)11-14(15)16(21-17)12-7-5-4-6-8-12/h4-11,17H,1-3H3/t17-/m0/s1
InChI KeyPXBVEXGRHZFEOF-KRWDZBQOSA-N
SMILESCN(C)C(=O)O[C@@H]1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (S)-Camazepam
  • 102818-70-2
  • 52O0W2O5SE
  • Camazepam, (S)-
  • Carbamic acid, dimethyl-, (3S)-7-chloro-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl ester, (S)-

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC601288
  • UNII-52O0W2O5SE
  • SCHEMBL156796

Physico-Chemical properties

IUPAC name[(3S)-7-chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl] N,N-dimethylcarbamate
Molecular formulaC19H18ClN3O3
Molecular weight371.818
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity106.94
LogP2.7
Topological polar surface area62.2

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.