Enprofylline

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Enprofylline are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the Enprofylline?

The molecule Enprofylline presents a molecular formula of C8H10N4O2 and its IUPAC name is 3-propyl-7H-purine-2,6-dione.

Enprofylline is a xanthine derivative used as a bronchodilator and to treat asthma. It is structurally similar to theophylline and caffeine. Enprofylline has a longer half-life than theophylline..

Enprofylline is used as a bronchodilator and to treat asthma. It is structurally similar to theophylline and caffeine. Enprofylline has a longer half-life than theophylline..

Enprofylline is a white, crystalline powder that is insoluble in water. The chemical structure is:.

CAS number .

Theophylline, another xanthine derivative, is structurally similar to enprofylline. The two compounds differ in the substituents on their respective nitrogen atoms. Theophylline has a shorter half-life than enprofylline..

Caffeine, another xanthine derivative, is also structurally similar to enprofylline. Caffeine has a shorter half-life than enprofylline..

3D structure

Cartesian coordinates

Geometry of Enprofylline in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

Enprofylline SIQPXVQCUCHWDI-UHFFFAOYSA-N chemical compound 2D structure molecule svg
Enprofylline

 

Molecule descriptors

 
IUPAC name3-propyl-7H-purine-2,6-dione
InChI codeInChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)
InChI KeySIQPXVQCUCHWDI-UHFFFAOYSA-N
SMILESCCCn1c(=O)[nH]c(=O)c2[nH]cnc21

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • 1H-Purine-2,6-dione, 3,7-dihydro-3-propyl-
  • 3,7-Dihydro-3-propyl-1H-purine-2,6-dione
  • 3-Propyl-1H-purine-2,6(3H,7H)-dione
  • 3-Propyl-3,7-dihydro-purine-2,6-dione
  • 3-Propyl-3,7-dihydro-purine-2,6-dione(enprofylline)
  • 3-Propylxanthfine
  • 3-Propylxanthine
  • 3-Propylxanthine (enprofylline)
  • 3-n-Propylxanthine
  • 3-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
  • 3-propyl-3,7-dihydro-1H-purine-2,6-dione
  • 3-propyl-7H-purine-2,6-dione
  • 41078-02-8
  • A914216
  • BCP14343
  • BDBM50001493
  • CCG-204992
  • CS-0003206
  • D 4028
  • D-4028
  • D04006
  • DB-049711
  • DB00824
  • DSSTox_CID_25186
  • DSSTox_GSID_45186
  • DSSTox_RID_80733
  • DT7DT5E518
  • ENPROFYLLINE
  • EU-0100910
  • Enprofilina
  • Enprofylline
  • Enprofylline (USAN/INN)
  • Enprofyllinum
  • FT-0630617
  • HMS2234D09
  • HMS3262F22
  • HMS3369J09
  • HY-14117
  • L000242
  • LP00910
  • Lopac-P-5679
  • Lopac0_000910
  • MLS000069700
  • NCGC00015824-01
  • NCGC00015824-02
  • NCGC00015824-03
  • NCGC00015824-04
  • NCGC00015824-05
  • NCGC00015824-06
  • NCGC00015824-07
  • NCGC00015824-08
  • NCGC00015824-09
  • NCGC00022716-03
  • NCGC00022716-04
  • NCGC00022716-05
  • NCGC00261595-01
  • Nilyph
  • P 5679
  • PDSP1_001019
  • PDSP1_001202
  • PDSP2_001003
  • PDSP2_001186
  • Q5379482
  • SDCCGSBI-0050885.P002
  • SMR000058496
  • SR-01000000173
  • SR-01000000173-2
  • Z1945707486

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC403567
  • CAS-41078-02-8
  • UNII-DT7DT5E518
  • AKOS006271777
  • AKOS013464325
  • DTXSID9045186
  • CHEMBL279898
  • CHEBI:126237
  • Tox21_110232
  • Tox21_500910
  • EINECS 255-201-8
  • SCHEMBL156402
  • SCHEMBL18029491

Physico-Chemical properties

IUPAC name3-propyl-7H-purine-2,6-dione
Molecular formulaC8H10N4O2
Molecular weight194.191
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity51.85
LogP-0.2
Topological polar surface area83.5

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.