A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (1R,3S)-5-hydroxy-2-adamantanone are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (1R,3S)-5-hydroxy-2-adamantanone?

The molecule (1R,3S)-5-hydroxy-2-adamantanone presents a molecular formula of C10H14O2 and its IUPAC name is (1R,3S)-5-hydroxyadamantan-2-one.

Adamantanones are a class of molecules with a wide range of potential applications. 5-Hydroxy-2-adamantanone, also known as 5-OH-Ada, is a member of this class. 5-OH-Ada has shown promise as a therapeutic agent for treating Alzheimer's disease and other neurological disorders..

Alzheimer's disease is a progressive neurodegenerative disorder characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. 5-OH-Ada has been shown to inhibit the formation of amyloid plaques in vitro. In addition, 5-OH-Ada has been shown to improve cognitive function in animal models of Alzheimer's disease..

5-OH-Ada has also been shown to have antidepressant and anxiolytic effects in animal models. The mechanism of action of 5-OH-Ada in the treatment of neurological disorders is not fully understood, but it is thought to involve the modulation of neurotransmitter systems..

5-OH-Ada is a promising therapeutic agent for the treatment of Alzheimer's disease and other neurological disorders. Further research is needed to elucidate the mechanism of action of 5-OH-Ada and to determine the efficacy and safety of 5-OH-Ada in humans..

3D structure

Cartesian coordinates

Geometry of (1R,3S)-5-hydroxy-2-adamantanone in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing


(1R,3S)-5-hydroxy-2-adamantanone TZBDEVBNMSLVKT-VZCHMASFSA-N chemical compound 2D structure molecule svg


Molecule descriptors

IUPAC name(1R,3S)-5-hydroxyadamantan-2-one
InChI codeInChI=1S/C10H14O2/c11-9-7-1-6-2-8(9)5-10(12,3-6)4-7/h6-8,12H,1-5H2/t6?,7-,8+,10?

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (1R,3S)-5-hydroxy-2-adamantanone
  • (1R,3S)-5-oxidanyladamantan-2-one
  • (1R,3S,7s)-5-hydroxytricyclo[,7~]decan-2-one
  • 098H140
  • A814237
  • AS-37886
  • BCP00873
  • BP-10634
  • GEO-01502
  • NCGC00166261-01
  • STK095803
  • W-200207

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC12362955
  • ZINC100011551
  • ZINC102250655
  • ZINC102250660
  • ZINC111919638
  • AKOS005395239
  • AKOS030211028
  • CHEMBL2001266
  • SCHEMBL3506706
  • SCHEMBL3506711
  • SCHEMBL3506713

Physico-Chemical properties

IUPAC name(1R,3S)-5-hydroxyadamantan-2-one
Molecular formulaC10H14O2
Molecular weight166.217
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity45.24
Topological polar surface area37.3

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.