(-)-Thalidomide

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (-)-Thalidomide are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (-)-Thalidomide?

The molecule (-)-Thalidomide presents a molecular formula of C13H10N2O4 and its IUPAC name is 2-[(3S)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione.

Thalidomide is a medication used to treat morning sickness and nausea in pregnant women. It is also used to treat certain blood disorders, such as anemia and leprosy..

Thalidomide was first approved for use in West Germany in 1957. It was later approved for use in the United States in 1960. However, thalidomide was pulled from the market in 1962 after it was linked to birth defects..

Thalidomide is a white, odorless, crystalline powder. It is soluble in water and insoluble in alcohol..

The exact mechanism of action of thalidomide is unknown. However, it is thought to work by inhibiting the production of certain inflammatory chemicals..

Thalidomide exists in oral and injectable forms. It is usually taken once or twice a day..

Common side effects of thalidomide include drowsiness, constipation, and dizziness. Thalidomide can also cause birth defects..

Thalidomide should not be used by pregnant women or women who are planning to become pregnant. It should also not be used by women who are breastfeeding..

Thalidomide is a potentially dangerous medication and should be used with caution..

3D structure

Cartesian coordinates

Geometry of (-)-Thalidomide in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

(-)-Thalidomide UEJJHQNACJXSKW-VIFPVBQESA-N chemical compound 2D structure molecule svg
(-)-Thalidomide

 

Molecule descriptors

 
IUPAC name2-[(3S)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione
InChI codeInChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m0/s1
InChI KeyUEJJHQNACJXSKW-VIFPVBQESA-N
SMILESO=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (-)-Thalidomide
  • (?)-Thalidomide
  • (S)-(-)-thalidomide
  • (S)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • (S)-Thalidomide
  • 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-, (S)-
  • 2-[(3S)-2,6-bis(oxidanylidene)piperidin-3-yl]isoindole-1,3-dione
  • 2-[(3S)-2,6-dioxo-3-piperidinyl]isoindole-1,3-dione
  • 2-[(3S)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione
  • 2-[(3S)-2,6-dioxopiperidin-3-yl]-2,3-dihydro-1H-isoindole-1,3-dione
  • 2-[(3S)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione
  • 4ci1
  • 841-67-8
  • A828082
  • BDBM65457
  • CS-0021928
  • EF2
  • ENMD 0995
  • ENMD-0995
  • HMS2230K15
  • HY-14658A
  • Lopac-T-144
  • MLS001333073
  • MLS001333074
  • NCGC00015989-01
  • NCGC00015989-02
  • NCGC00016220-01
  • NCGC00024708-01
  • NSC 91730
  • NSC-91730
  • Phthalimide, N-(2,6-dioxo-3-piperidyl)-, (-)-
  • Phthalimide, N-(2,6-dioxo-3-piperidyl)-, L-(-)-
  • Q27131493
  • S(-)-3-(3-AMINO-PHTHALIMIDO)-GLUTARAMIDE
  • S-(-)-Thalidomide
  • S-Thalidomide
  • SMR000857221
  • TG87FSR590
  • Thalidomide, (-)-
  • Thalidomide, (S)-
  • Thalidomide, L-
  • Thalidomide; N-(2,6-dioxo-3-piperidyl)phalimide
  • Tocris-0652
  • l-Thalidomide
  • rac-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC1530947
  • CAS-50-35-1
  • UNII-TG87FSR590
  • DTXSID1046972
  • CHEMBL426123
  • CHEBI:61918
  • SCHEMBL455269

Physico-Chemical properties

IUPAC name2-[(3S)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione
Molecular formulaC13H10N2O4
Molecular weight258.23
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity70.95
LogP0.4
Topological polar surface area83.6

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.