A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (S)-Hexobarbital are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (S)-Hexobarbital?

The molecule (S)-Hexobarbital presents a molecular formula of C12H16N2O3 and its IUPAC name is (5S)-5-(cyclohexen-1-yl)-1,5-dimethyl-1,3-diazinane-2,4,6-trione.

Hexobarbital is a short-acting barbiturate. It is a white, odorless, crystalline powder with a bitter taste. It dissolves in water and is used as an intravenous anesthetic..

Hexobarbital is used as an anesthetic for short-term surgery and as a sedative for some medical procedures. It is also used to treat insomnia and to help people sleep before surgery. Hexobarbital is also used as a lethal injection for capital punishment..

The effects of hexobarbital usually last for 4 to 6 hours. Hexobarbital can be habit-forming and can lead to dependence and addiction..

Hexobarbital is a schedule II drug in the United States. It exists as a generic drug..

3D structure

Cartesian coordinates

Geometry of (S)-Hexobarbital in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing


(S)-Hexobarbital UYXAWHWODHRRMR-LBPRGKRZSA-N chemical compound 2D structure molecule svg


Molecule descriptors

IUPAC name(5S)-5-(cyclohexen-1-yl)-1,5-dimethyl-1,3-diazinane-2,4,6-trione
InChI codeInChI=1S/C12H16N2O3/c1-12(8-6-4-3-5-7-8)9(15)13-11(17)14(2)10(12)16/h6H,3-5,7H2,1-2H3,(H,13,15,17)/t12-/m0/s1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (+)-Hexobarbital
  • (+)-Hexobarbitone
  • (-)-Hexobarbital
  • (S)-Hexobarbital
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-cyclohexen-1-yl)-1,5-dimethyl-, (R)-
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-cyclohexen-1-yl)-1,5-dimethyl-, (S)-
  • 5-(1-Cyclohex-en-1-yl)-1,5-dimethylbarbituric acid
  • 5-(1-Cyclohexene-1-yl)-1,5-dimethylbarbituric acid
  • 7245-04-7
  • 7245-06-9

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC3830910
  • SCHEMBL59121

Physico-Chemical properties

IUPAC name(5S)-5-(cyclohexen-1-yl)-1,5-dimethyl-1,3-diazinane-2,4,6-trione
Molecular formulaC12H16N2O3
Molecular weight236.267
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity69.35
Topological polar surface area66.5

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.