(6R)-Folinic acid

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (6R)-Folinic acid are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (6R)-Folinic acid?

The molecule (6R)-Folinic acid presents a molecular formula of C20H23N7O7 and its IUPAC name is (2S)-2-[[4-[[(6R)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid.

Folinic acid (6R)-L-glutamate is an important molecule in one-carbon metabolism. It is a derivative of folic acid and is used as a coenzyme in the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Folinic acid is also used in the treatment of megaloblastic anemias..

3D structure

Cartesian coordinates

Geometry of (6R)-Folinic acid in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing


(6R)-Folinic acid VVIAGPKUTFNRDU-OLZOCXBDSA-N chemical compound 2D structure molecule svg
(6R)-Folinic acid


Molecule descriptors

IUPAC name(2S)-2-[[4-[[(6R)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
InChI codeInChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13+/m1/s1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (2S)-2-[[4-[[(6R)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
  • (2S)-2-[[4-[[(6R)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
  • (6R)-5-Formyl-5,6,7,8-tetrahydrofolic acid
  • (6R)-5-Formyltetrahydrofolic acid
  • (6R)-Folinic acid
  • (6R)-Leucovorin
  • (6R,2'S)-Folinic acid
  • (6r,s)-5-formyltetrahydrofolic acid
  • (S)-2-(4-((((R)-2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid
  • 58-05-9
  • 6R-Leucovorin
  • 73951-54-9
  • DB03256
  • Dextrofolinic acid
  • L-Glutamic acid, N-(4-((((6R)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
  • L-Glutamic acid, N-[4-[[[(6R)-2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-
  • N-{[4-({[(6r)-2-Amino-5-Formyl-4-Oxo-1,4,5,6,7,8-Hexahydropteridin-6-Yl]methyl}amino)phenyl]carbonyl}-L-Glutamic Acid
  • Q27094183
  • [6R]-5-formyl-5,6,7,8-tetrahydrofolate

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC9212428
  • DTXSID10224654
  • CHEMBL1232801
  • SCHEMBL21498299

Physico-Chemical properties

IUPAC name(2S)-2-[[4-[[(6R)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
Molecular formulaC20H23N7O7
Molecular weight473.439
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity126.52
Topological polar surface area219.8

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.