Morphine-3-glucuronide
A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Morphine-3-glucuronide are summarized together with 3D and 2D structures and relevant physico-chemical properties.
Table of Contents
What is the Morphine-3-glucuronide?
The molecule Morphine-3-glucuronide presents a molecular formula of C23H27NO9 and its IUPAC name is (2S,3S,4S,5R,6S)-6-[[(4R,4aR,7S,7aR,12bS)-7-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid.
Morphine-3-glucuronide (M3G) is an active metabolite of morphine that is formed by the conjugation of morphine with glucuronic acid. M3G is pharmacologically active and is a potent agonist at the μ-opioid receptor. The analgesic potency of M3G is approximately one-tenth that of morphine. The elimination half-life of M3G is shorter than that of morphine, and it is primarily excreted in the urine..
M3G was first described in the early 1970s and its structure was elucidated in the late 1980s. M3G is formed in vivo by the conjugation of morphine with glucuronic acid. This reaction is catalyzed by UDP-glucuronosyltransferases (UGTs). M3G is pharmacologically active and is a potent agonist at the μ-opioid receptor. The analgesic potency of M3G is approximately one-tenth that of morphine. The elimination half-life of M3G is shorter than that of morphine, and it is primarily excreted in the urine..
M3G has a number of advantages over morphine. First, the shorter elimination half-life results in a more rapid onset of action. Second, M3G is less likely to accumulate in the body and produce adverse effects. Finally, M3G is less likely to be associated with the development of tolerance and dependence..
3D structure
Cartesian coordinates
Geometry of Morphine-3-glucuronide in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.
2D drawing
Molecule descriptors
| IUPAC name | (2S,3S,4S,5R,6S)-6-[[(4R,4aR,7S,7aR,12bS)-7-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid |
| InChI code | InChI=1S/C23H27NO9/c1-24-7-6-23-10-3-4-12(25)20(23)32-18-13(5-2-9(14(18)23)8-11(10)24)31-22-17(28)15(26)16(27)19(33-22)21(29)30/h2-5,10-12,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,12-,15-,16-,17+,19-,20-,22+,23-/m0/s1 |
| InChI Key | WAEXKFONHRHFBZ-ZXDZBKESSA-N |
| SMILES | CN1CC[C@]23c4c5ccc(O[C@@H]6O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]6O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5 |
Other names (synonyms)
IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.
One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.
Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.
In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.
- (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(1S,5R,13R,14S,17R)-14-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15-tetraen-10-yl]oxy}oxane-2-carboxylic acid
- (2S,3S,4S,5R,6S)-6-[[(4R,4aR,7S,7aR,12bS)-7-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
- (2S,3S,4S,5R,6S)-6-[[(4R,4aR,7S,7aR,12bS)-7-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-9-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
- .BETA.-D-GLUCOPYRANOSIDURONIC ACID
- .beta.-D-Glucopyranosiduronic acid, (5.alpha.,6.alpha.)-7,8-didehydro-4,5-epoxy-6-hydroxy-17-methylmorphinan-3-yl
- 20290-09-9
- 4-MORPHOLIN-4-YL-2-PHENYL-BUTYRICACID
- BDBM224029
- GLUCOPYRANOSIDURONIC ACID, MORPHINE-3, .BETA.-D-
- MORPHINE 3-GLUCURONIDE(MINOR)
- MORPHINE 3-O-.BETA.-D-GLUCURONIDE
- Morphine 3-?-D-Glucuronide
- Morphine 3-beta-D-glucuronide
- Morphine 3-glucuronide
- Morphine-3-beta-D-glucuronide
- Morphine-3-glucuronide
- Morphine-3G
- O27Z9CH39A
- Q65707098
- beta-D-Glucopyranosiduronic acid, (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-6-hydroxy-17-methylmorphinan-3-yl
- morphin-3-glucuronid
Reference codes for other databases
There exist several different chemical codes commonly used in orded to identify molecules:- CAS number (Chemical Abstracts Service Registry Number) is a unique identifier is assigned to every chemical compound indexed in the CAS database.
- Beilstein: The Beilstein database is a comprehensive source of information on organic chemistry, including information on chemical structures, properties, and reactions. The Beilstein database assigns unique identifiers which can be used to identify compounds in scientific literature and other sources.
- ChEBI (Chemical Entities of Biological Interest): ChEBI is a database of small chemical molecules that are of interest in the field of biology.
- PubChem CID (Compound Identifier): PubChem is a database of chemical compounds that is maintained by the National Institutes of Health (NIH).
- RTECS number (Registry of Toxic Effects of Chemical Substances): The RTECS is a database of information on the toxic effects of chemicals, including information on their structures and properties.
- ChEMBL (Compound Bioactivity Data): ChEMBL is a database of bioactivity data for small molecules, including information on their properties and structures.
- CompTox Dashboard (Environmental Protection Agency): The CompTox Dashboard is a database of information on the toxicology and environmental effects of chemicals.
- ZINC30731319
- UNII-O27Z9CH39A
- DTXSID80174157
- CHEMBL1329
- CHEBI:80631
- SCHEMBL3843209
Physico-Chemical properties
| IUPAC name | (2S,3S,4S,5R,6S)-6-[[(4R,4aR,7S,7aR,12bS)-7-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid |
| Molecular formula | C23H27NO9 |
| Molecular weight | 461.462 |
| Melting point (ºC) | |
| Boiling point (ºC) | |
| Density (g/cm3) | |
| Molar refractivity | 115.00 |
| LogP | -1.3 |
| Topological polar surface area | 149.2 |
LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.
The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.
TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.
In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.
For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.