A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (R)-Norfluoxetine are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (R)-Norfluoxetine?

The molecule (R)-Norfluoxetine presents a molecular formula of C16H16F3NO and its IUPAC name is (3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine.

R-Norfluoxetine is a molecule that is used in the treatment of depression and anxiety. It is a selective serotonin reuptake inhibitor (SSRI), meaning it inhibits the reuptake of serotonin in the brain. This increases the level of serotonin available to the brain, which leads to improved mood and decreased anxiety. R-Norfluoxetine is the active ingredient in the antidepressant medication Prozac..

3D structure

Cartesian coordinates

Geometry of (R)-Norfluoxetine in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing


(R)-Norfluoxetine WIQRCHMSJFFONW-OAHLLOKOSA-N chemical compound 2D structure molecule svg


Molecule descriptors

IUPAC name(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
InChI codeInChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2/t15-/m1/s1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (3r)-3-Phenyl-3-[4-(Trifluoromethyl)phenoxy]propan-1-Amine
  • (R)-3-(4-Trifluoromethylphenoxy)-3-phenylpropylamine
  • (R)-3-4-(Trifluoromethyl)phenoxy-3-phenylpropan-1-amine hydrochloride
  • (R)-3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine
  • (R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine
  • (R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine, AldrichCPR
  • (R)-Norfluoxetine
  • 05UQ1299DN
  • 130194-43-3
  • BDBM50254791
  • Benzenepropanamine, gamma-(4-(trifluoromethyl)phenoxy)-, (gammaR)-
  • Benzenepropanamine, gamma-[4-(trifluoromethyl)phenoxy]-, (gammaR)-
  • J-005760
  • Norfluoxetine, (R)-
  • Q27236142
  • R-Norfluoxetine

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC1645453
  • UNII-05UQ1299DN
  • AKOS027384575
  • CHEMBL446084
  • SCHEMBL3750512

Physico-Chemical properties

IUPAC name(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
Molecular formulaC16H16F3NO
Molecular weight295.3
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity74.74
Topological polar surface area35.3

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.