Nilutamide
A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Nilutamide are summarized together with 3D and 2D structures and relevant physico-chemical properties.
Table of Contents
What is the Nilutamide?
The molecule Nilutamide presents a molecular formula of C12H10F3N3O4 and its IUPAC name is 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione.
Nilutamide is a nonsteroidal antiandrogen (NSAA) that is used in the treatment of prostate cancer. It is a member of the arylacetamide class of NSAA..
Nilutamide was first synthesized in 1977 by Japanese chemist Akira Endo while working for Sankyo Pharma. It was initially developed as an oral contraceptive. However, it was found to have antiandrogenic activity and was further studied for the treatment of prostate cancer..
Nilutamide is approved for the treatment of metastatic prostate cancer in Japan and Europe. It is not approved in the United States, but exists through the FDA's compassionate use program..
Nilutamide is an inhibitor of androgen receptor (AR) signaling. It binds to the androgen receptor and prevents it from binding to androgens. This leads to a decrease in androgen receptor activity and a decrease in the growth of prostate cancer cells..
Nilutamide has been shown to be effective in the treatment of metastatic prostate cancer. In a large clinical trial, nilutamide was found to prolong survival in men with metastatic prostate cancer..
Nilutamide is generally well-tolerated. The most common side effects are gastrointestinal and include nausea, vomiting, and diarrhea. Other side effects include hot flashes, impotence, and gynecomastia..
Nilutamide is a potent and effective inhibitor of androgen receptor signaling. It is well-tolerated and has been shown to prolong survival in men with metastatic prostate cancer..
3D structure
Cartesian coordinates
Geometry of Nilutamide in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.
2D drawing
Molecule descriptors
| IUPAC name | 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione |
| InChI code | InChI=1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20) |
| InChI Key | XWXYUMMDTVBTOU-UHFFFAOYSA-N |
| SMILES | CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O |
Other names (synonyms)
IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.
One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.
Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.
In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.
- 1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethylimidazolidine-2,5-dione
- 1-(3'-trifluoromethyl-4'-nitrophenyl)-4,4-dimethyl-imidazoline-2,5-dione
- 1-(3'-trifluoromethyl-4'-nitrophenyl)4,4-dimethyl-imidazoline-2,5-dione
- 1-(3'-trifluoromethyl-4'nitrophenyl)-4,4-dimethyl-imidazoline-2,5-dione
- 1-(3'trifluoromethyl-4'-nitropheyl)-4,4-dimethyl-imidazoline-2,5-dione
- 1-(3-'trifluoromethyl-4'-nitrophenyl)-4,4-dimethyl-imidazoline-2,5-dione
- 1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl imidazolidine-2,5-dione
- 1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl-imidazolidine-2,5-dione
- 1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl-imidazoline-2,5-dione
- 1-(3-trifluoromethyl-4-nitrophenyl)-4,4-dimethyl-imidazoline-2,5-dione
- 2,4-IMIDAZOLIDINEDIONE, 5,5-DIMETHYL-3-(4-NITRO-3-(TRIFLUOROMETHYL)PHENYL)-
- 2,4-Imidazolidinedione, 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-
- 2,4-Imidazolidinedione,5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-
- 3-(3-(trifluoromethyl)-4-nitrophenyl)-5,5-dimethylimidazolidine-2,4-dione
- 5,5-DIMETHYL-3-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-4-NITRO-M-TOLYL)HYDANTOIN
- 5,5-Dimethyl-3-(4-nitro-3-(trifluoromethyl)-phenyl)imidazolidine-2,4-dione
- 5,5-Dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-2,4-imidazolidinedione
- 5,5-Dimethyl-3-(4-nitro-3-trifluoromethyl-phenyl)-imidazolidine-2,4-dione
- 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin
- 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
- 5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione
- 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-1,3-diazolidine-2,4-dione
- 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-imidazolidine-2,4-dione
- 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
- 51G6I8B902
- 612N500
- 63612-50-0
- A834440
- AB00053180
- AB00053180_07
- AC-5260
- AMY32529
- AS-14123
- Anandron
- BCP26617
- BCP9000990
- BCPP000148
- BDBM50135912
- BIDD:GT0683
- BIDD:PXR0177
- BN166184
- BPBio1_000920
- BRN 0841906
- BSPBio_000836
- BSPBio_003325
- C08164
- CCG-39427
- CS-0007719
- D00965
- DB00665
- DSSTox_CID_14165
- DSSTox_GSID_34165
- DSSTox_RID_79118
- DivK1c_006998
- EU-0100879
- FT-0630740
- GTPL2864
- HMS1570J18
- HMS1922F03
- HMS2093A10
- HMS2097J18
- HMS2230E03
- HMS3262P19
- HMS3268C18
- HMS3369I02
- HMS3414N15
- HMS3678N13
- HMS3714J18
- HY-13702
- KBio1_001942
- KBio2_002105
- KBio2_004673
- KBio2_007241
- KBio3_002545
- KBioGR_001100
- KBioSS_002105
- L000759
- LP00879
- Lopac-N-8534
- Lopac0_000879
- MFCD00864670
- MLS002154066
- N 8534
- N1212
- NCGC00015754-01
- NCGC00015754-02
- NCGC00015754-03
- NCGC00015754-04
- NCGC00015754-05
- NCGC00015754-06
- NCGC00015754-07
- NCGC00015754-08
- NCGC00015754-09
- NCGC00015754-10
- NCGC00015754-11
- NCGC00015754-12
- NCGC00015754-15
- NCGC00015754-16
- NCGC00015754-22
- NCGC00025280-01
- NCGC00025280-02
- NCGC00025280-03
- NCGC00025280-04
- NCGC00025280-05
- NCGC00025280-06
- NCGC00025280-07
- NCGC00025280-08
- NCGC00255271-01
- NCGC00261564-01
- NSC 758683
- NSC-758683
- NSC758683
- Nilandron
- Nilandron;RU 23908
- Nilandrone
- Nilutamida
- Nilutamide
- Nilutamide (USAN/INN)
- Nilutamide, solid
- Nilutamidum
- Pharmakon1600-01504152
- Prestwick0_000928
- Prestwick1_000928
- Prestwick2_000928
- Prestwick3_000928
- Q3877030
- RU 23908
- RU 23908-10
- RU-23908
- RU-23908;RU 23908;RU23908
- RU23908
- SB19036
- SBI-0050854.P003
- SDCCGSBI-0050854.P004
- SMR001233381
- SPECTRUM1504152
- SR-01000076034
- SR-01000076034-1
- SR-01000076034-3
- SR-01000076034-5
- SR-01000076034-6
- SR-01000076034-9
- STK633161
- SpecPlus_000902
- Tocris-1759
- Tox21 110213
- Z2417927201
- diethyl1,4-dihydro-2,6-dimethyl-1,4-diphenyl-3,5-pyridinedicarboxylate
- nilutamide
- s4836
Reference codes for other databases
There exist several different chemical codes commonly used in orded to identify molecules:- CAS number (Chemical Abstracts Service Registry Number) is a unique identifier is assigned to every chemical compound indexed in the CAS database.
- Beilstein: The Beilstein database is a comprehensive source of information on organic chemistry, including information on chemical structures, properties, and reactions. The Beilstein database assigns unique identifiers which can be used to identify compounds in scientific literature and other sources.
- ChEBI (Chemical Entities of Biological Interest): ChEBI is a database of small chemical molecules that are of interest in the field of biology.
- PubChem CID (Compound Identifier): PubChem is a database of chemical compounds that is maintained by the National Institutes of Health (NIH).
- RTECS number (Registry of Toxic Effects of Chemical Substances): The RTECS is a database of information on the toxic effects of chemicals, including information on their structures and properties.
- ChEMBL (Compound Bioactivity Data): ChEMBL is a database of bioactivity data for small molecules, including information on their properties and structures.
- CompTox Dashboard (Environmental Protection Agency): The CompTox Dashboard is a database of information on the toxicology and environmental effects of chemicals.
- ZINC3874498
- CAS-63612-50-0
- UNII-51G6I8B902
- AKOS005565152
- AKOS025147305
- BRD-K23566484-001-05-2
- BRD-K23566484-001-09-4
- DTXSID3034165
- CHEMBL1274
- CHEBI:7573
- Tox21_110213
- Tox21_301589
- Tox21_500879
- Tox21_110213_1
- SPBio_002125
- SPBio_003015
- SCHEMBL12670
- Spectrum_001625
- Spectrum2_001973
- Spectrum3_001633
- Spectrum4_000600
- Spectrum5_001512
Physico-Chemical properties
| IUPAC name | 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione |
| Molecular formula | C12H10F3N3O4 |
| Molecular weight | 317.221 |
| Melting point (ºC) | |
| Boiling point (ºC) | |
| Density (g/cm3) | |
| Molar refractivity | 77.26 |
| LogP | 3.4 |
| Topological polar surface area | 95.2 |
LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.
The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.
TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.
In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.
For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.