Clobetasone

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for Clobetasone are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the Clobetasone?

The molecule Clobetasone presents a molecular formula of C₂₂H₂₆ClFO₄ and its IUPAC name is (8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione.

Clobetasone is a synthetic glucocorticoid corticosteroid which is marketed under a variety of brand names including ClobaDerm, Cormax, Embeline, Tenovate, and Temovate. It is used topically to treat various skin disorders such as eczema, psoriasis, and dermatitis. Clobetasone is a prodrug of clobetasol, and the two compounds are often used interchangeably..

Clobetasone was first synthesized in 1955, and was introduced for medical use in 1966. It exists as a cream, ointment, or solution. A gel formulation was approved for use in the United States in July 2014. Clobetasone is also available in combination with other drugs such as an antibiotic or antifungal..

The most common side effects of clobetasone are burning, itching, stinging, and redness at the site of application. Clobetasone is a potent glucocorticoid and can cause adrenal suppression if used for extended periods of time. It should not be used in children under the age of 12, or in pregnant or breastfeeding women..

Clobetasone is a glucocorticoid receptor agonist with high affinity for the mineralocorticoid receptor and low affinity for the glucocorticoid receptor. It is a prodrug of clobetasol, and the two compounds are often used interchangeably. Clobetasone is used topically to treat various skin disorders such as eczema, psoriasis, and dermatitis. It exists as a cream, ointment, or solution. A gel formulation was approved for use in the United States in July 2014. Clobetasone is also available in combination with other drugs such as an antibiotic or antifungal..

The most common side effects of clobetasone are burning, itching, stinging, and redness at the site of application. Clobetasone is a potent glucocorticoid and can cause adrenal suppression if used for extended periods of time. It should not be used in children under the age of 12, or in pregnant or breastfeeding women..

3D structure

Cartesian coordinates

Geometry of Clobetasone in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

Molecule descriptors

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

Reference codes for other databases

• CAS number (Chemical Abstracts Service Registry Number) is a unique identifier is assigned to every chemical compound indexed in the CAS database.
• Beilstein: The Beilstein database is a comprehensive source of information on organic chemistry, including information on chemical structures, properties, and reactions. The Beilstein database assigns unique identifiers which can be used to identify compounds in scientific literature and other sources.
• ChEBI (Chemical Entities of Biological Interest): ChEBI is a database of small chemical molecules that are of interest in the field of biology.
• PubChem CID (Compound Identifier): PubChem is a database of chemical compounds that is maintained by the National Institutes of Health (NIH).
• RTECS number (Registry of Toxic Effects of Chemical Substances): The RTECS is a database of information on the toxic effects of chemicals, including information on their structures and properties.
• ChEMBL (Compound Bioactivity Data): ChEMBL is a database of bioactivity data for small molecules, including information on their properties and structures.
• CompTox Dashboard (Environmental Protection Agency): The CompTox Dashboard is a database of information on the toxicology and environmental effects of chemicals.

Physico-Chemical properties

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (K_ow) data is applied in toxicology and drug research. K_ow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(K_ow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Ų are required. Thus, molecules with a polar surface area greater than 140 Ų tend to be poorly permeable to cell membranes.