(S)-Modafinil

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (S)-Modafinil are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (S)-Modafinil?

The molecule (S)-Modafinil presents a molecular formula of C15H15NO2S and its IUPAC name is 2-[(S)-benzhydrylsulfinyl]acetamide.

(S)-Modafinil is a molecule that is used in the treatment of narcolepsy and other sleep disorders. It is a wakefulness-promoting agent that acts on the central nervous system. It is structurally similar to the stimulant amphetamine and has similar effects on the brain. However, modafinil is not a controlled substance and has a lower potential for abuse than amphetamines..

3D structure

Cartesian coordinates

Geometry of (S)-Modafinil in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

(S)-Modafinil YFGHCGITMMYXAQ-IBGZPJMESA-N chemical compound 2D structure molecule svg
(S)-Modafinil

 

Molecule descriptors

 
IUPAC name2-[(S)-benzhydrylsulfinyl]acetamide
InChI codeInChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m0/s1
InChI KeyYFGHCGITMMYXAQ-IBGZPJMESA-N
SMILESNC(=O)C[S@](=O)C(c1ccccc1)c1ccccc1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (+)-Modafinil
  • (S)-(+)-Modafinil
  • (S)-Modafinil
  • 112111-47-4
  • 152JRG3T0U
  • 2-((S)-(DIPHENYLMETHYL)SULFINYL)ACETAMIDE
  • 2-[(S)-(Diphenylmethyl)sulfinyl]acetamide
  • 2-[(S)-benzhydrylsulfinyl]acetamide
  • Acetamide, 2-((S)-(diphenylmethyl)sulfinyl)-
  • BDBM50336893
  • CRL 40983
  • CRL-40983
  • Modafinil, (+)-
  • Modafinil, (S)-
  • NH 02D
  • NH-02D
  • Q27147194

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC3831139
  • DTXSID70457709
  • CHEMBL1672355
  • CHEBI:77591
  • SCHEMBL1403524

Physico-Chemical properties

IUPAC name2-[(S)-benzhydrylsulfinyl]acetamide
Molecular formulaC15H15NO2S
Molecular weight273.35
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity76.69
LogP3.6
Topological polar surface area79.4

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.