(6R)-5-Methyltetrahydrofolic acid

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (6R)-5-Methyltetrahydrofolic acid are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (6R)-5-Methyltetrahydrofolic acid?

The molecule (6R)-5-Methyltetrahydrofolic acid presents a molecular formula of C20H25N7O6 and its IUPAC name is (2S)-2-[[4-[[(6R)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid.

Tetrahydrofolic acid (THFA) is a folic acid derivative with a wide range of functions in the human body. It participes in the metabolism of nucleic acids and amino acids, and is required for the synthesis of DNA and RNA. THFA is also required for the synthesis of the amino acids methionine and cysteine, and for the production of the coenzyme tetrahydrofolate (THF). THFA belongs in a variety of foods, including leafy green vegetables, legumes, and liver..

In the body, THFA is converted to THF by the enzyme dihydrofolate reductase (DHFR). THF is then used in a variety of reactions, including the synthesis of DNA and RNA. THF is also required for the synthesis of the amino acids methionine and cysteine, and for the production of the coenzyme tetrahydrofolate (THF). THFA belongs in a variety of foods, including leafy green vegetables, legumes, and liver..

THFA is converted to THF by the enzyme dihydrofolate reductase (DHFR). THF is then used in a variety of reactions, including the synthesis of DNA and RNA. THF is also required for the synthesis of the amino acids methionine and cysteine, and for the production of the coenzyme tetrahydrofolate (THF). THFA belongs in a variety of foods, including leafy green vegetables, legumes, and liver..

THFA is an important molecule in the human body with a wide range of functions. It participes in the metabolism of nucleic acids and amino acids, and is required for the synthesis of DNA and RNA. THFA is also required for the synthesis of the amino acids methionine and cysteine, and for the production of the coenzyme tetrahydrofolate (THF). THFA belongs in a variety of foods, including leafy green vegetables, legumes, and liver..

3D structure

Cartesian coordinates

Geometry of (6R)-5-Methyltetrahydrofolic acid in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

(6R)-5-Methyltetrahydrofolic acid ZNOVTXRBGFNYRX-OLZOCXBDSA-N chemical compound 2D structure molecule svg
(6R)-5-Methyltetrahydrofolic acid

 

Molecule descriptors

 
IUPAC name(2S)-2-[[4-[[(6R)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
InChI codeInChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12-,13+/m1/s1
InChI KeyZNOVTXRBGFNYRX-OLZOCXBDSA-N
SMILESCN1c2c(nc(N)[nH]c2=O)NC[C@H]1CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (6R)-5-Methyltetrahydrofolic acid
  • (6r,s)-5-methyltetrahydrofolic acid
  • 5-methyl-(6R,S)-tetrahydrofolic acid

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC2572666
  • SCHEMBL7678398

Physico-Chemical properties

IUPAC name(2S)-2-[[4-[[(6R)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
Molecular formulaC20H25N7O6
Molecular weight459.456
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity125.93
LogP1.0
Topological polar surface area202.8

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.