(R)-Gemifloxacin

A summary of the most common chemical descriptors (InChI Key and SMILES codes) for (R)-Gemifloxacin are summarized together with 3D and 2D structures and relevant physico-chemical properties.

What is the (R)-Gemifloxacin?

The molecule (R)-Gemifloxacin presents a molecular formula of C18H20FN5O4 and its IUPAC name is 7-[(3R,4Z)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid.

Gemifloxacin (trade name Factive) is an oral quinolone antibiotic used to treat bacterial infections. It was developed by Oscient Pharmaceuticals and approved by the U.S. Food and Drug Administration in February 2003..

Gemifloxacin is a member of the class of drugs known as fluoroquinolones, which act by inhibiting the bacterial enzyme DNA gyrase, preventing the bacteria from replicating their DNA..

The most common side effects of gemifloxacin are gastrointestinal, including nausea, vomiting, diarrhea, and abdominal pain. Other common side effects include headache, dizziness, lightheadedness, and rash..

Gemifloxacin should not be used by people with a history of hypersensitivity to quinolones, or by people with a history of epilepsy or other seizure disorders..

Gemifloxacin exists in tablet form in strengths of 320 mg..

3D structure

Cartesian coordinates

Geometry of (R)-Gemifloxacin in x, y and z coordinates (Å units) to copy/paste elsewhere. Generated with Open Babel software.

2D drawing

 

(R)-Gemifloxacin ZRCVYEYHRGVLOC-APKGJDNQSA-N chemical compound 2D structure molecule svg
(R)-Gemifloxacin

 

Molecule descriptors

 
IUPAC name7-[(3R,4Z)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
InChI codeInChI=1S/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+/t9-/m1/s1
InChI KeyZRCVYEYHRGVLOC-APKGJDNQSA-N
SMILESCO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@H]1CN

Other names (synonyms)

IUPAC nomenclature provides a standardized method for naming chemical compounds. Although this system is widely used in chemistry, many chemical compounds have also other names commonly used in different contexts. These synonyms can come from a variety of sources and are used for a variety of purposes.

One common source of synonyms for chemical compounds is the common or trivial names, assigned on the basis of appearance, properties, or origin of the molecule.

Another source of synonyms are historical or obsolete names employed in the past, however replaced nowadays by more modern or standardized names.

In addition to common and historical names, chemical compounds may also have synonyms that are specific to a particular field or industry.

  • (R)-Gemifloxacin
  • 1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 7-((4Z)-3-(AMINOMETHYL)-4-(METHOXYIMINO)-1-PYRROLIDINYL)-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-, (R)-
  • GEMIFLOXACIN, (R)-
  • VJ8JLV45C6

Reference codes for other databases

There exist several different chemical codes commonly used in orded to identify molecules:
  • ZINC12503271
  • SCHEMBL3252334

Physico-Chemical properties

IUPAC name7-[(3R,4Z)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
Molecular formulaC18H20FN5O4
Molecular weight389.381
Melting point (ºC)
Boiling point (ºC)
Density (g/cm3)
Molar refractivity103.42
LogP1.7
Topological polar surface area123.0

LogP and topological polar surface area (TPSA) values were estimated using Open Babel software.

The n-octanol/water partition coeficient (Kow) data is applied in toxicology and drug research. Kow values are used, to guess the environmental fate of persistent organic pollutants. High partition coefficients values, tend to accumulate in the fatty tissue of organisms. Molecules with a log(Kow) (or LogP) greater than 5 are considered to bioaccumulate.

TPSA values are the sum of the surface area over all polar atoms or molecules, mainly oxygen and nitrogen, also including hydrogen atoms.

In medicinal chemistry, TPSA is used to assess the ability of a drug to permeabilise cells.

For molecules to penetrate the blood-brain barrier (and act on receptors in the central nervous system), TPSA values below 90 Å2 are required. Thus, molecules with a polar surface area greater than 140 Å2 tend to be poorly permeable to cell membranes.